Empirical Bayes Analysis of Quantitative Proteomics Experiments
نویسندگان
چکیده
منابع مشابه
Empirical Bayes Analysis of Quantitative Proteomics Experiments
BACKGROUND Advances in mass spectrometry-based proteomics have enabled the incorporation of proteomic data into systems approaches to biology. However, development of analytical methods has lagged behind. Here we describe an empirical Bayes framework for quantitative proteomics data analysis. The method provides a statistical description of each experiment, including the number of proteins that...
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the classical method of analysis of a series of experiments is somewhat involved in being conditional on various, occasionally unrealistic, assumptions such as homogeneity of variances of experimental error, lack of interactions of treatments and places,etc. in this work, we adopt a bayesian view to account for such heterogeneities. our appoach is illustrated by a real series of experiments reg...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0007454